Outlook Hangs On Loading Profile
Just leaving this here for future reference:TLDR: Try cutting off internet during Outlook startup.I used Process Monitor to see what Outlook was actually doing in my case when it is stuck on loading the profile. I saw a bunch of Telemetry and TCP related stuff which made me think it is trying to connect somewhere but does not succeed.Disabling all network interfaces during startup of Outlook immediately solved my problem. Outlook opened perfectly and once it is open, the network interfaces can be switched on again. For our situation we're 365 subscribers using Office 2016 on Win7 SP1 inside a VPN environment with Exchange Server 2013. Opening in Safe Mode allowed me to get Outlook open, then I disabled all but 2 add-ons (Skype Meetings and Exchange 2013). I disabled everything related to SharePoint, Social Media, and OneNote (who uses that?). After disabling the plugins Outlook would open normally.
Inside the VPN environment we can't reach SharePoint, OneNote, or social media channels normally, so one of them seemed to have been what Outlook was trying to connect to and couldn't reach in our case. Outlook 2016 hangs on loading profile for over 2 minutes.NON-WORKING SOLUTIONS:-1. Creating a new Outlook profile.2. Quick repair.3. Full repair (gave me an error and used Microsoft's tool to remove all office projects and re-installed everything.)4. Deleted the Outlook folder (including all OST files) and let things get re-created.5.
Outlook Stuck On Loading Profile Office 365

Disable hardware acceleration.6. Started outlook.exe /safe which opens fast.7. Disabled all COM add-ins.8. Disk Cleanup9.
All windows/office updates completed.10. Disabled IPv6.11. Ran the SARA (Support and Recovery Assistance) troubleshooting12. Tried the 'Run this program in compatibility mode for' on the shortcut.WORKING SOLUTION:-Disable the following network adapters:Microsoft Loopback AdapterNpcap Loopback AdapterAfter this, outlook would open within 5 seconds and not hang on loading profile anymore. I also you recommend to just disable any network adapter you're not using.OTHER THROUGHTS-Why does Outlook search other network adapters?.

Many people have reported problems when they try to start Outlook 2016 that Outlook keeps saying Loading Profile. I had this issue personally a few days ago and found out that removing your profiles does solve this. However be aware that removing your profiles does result in data loss. How to Remove Outlook Profiles in Windows 101. To begin right-click on the Start Menu and then choose Control Panel2. Once Control Panel has opened click on User Accounts3.
Outlook 2010 Loading Profile Takes A Long Time
Then once the User Accounts section of Control Panel has opened click on Mail (Microsoft Outlook 2016). Then once Mail Setup has opened click on Show Profiles5. Click on the first user profile and then choose Remove, repeat this step for all user profiles.After completing all the steps you can start Microsoft Outlo0k again, and outlook will ask you to set up your mail accounts like you had to do when you ran Outlook for the first time.While this isn’t the best solution, at the moment it does seem to like the only solution that always works.
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